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32 results

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Attenuation of cancer proliferation by suppression of glypican-1 and its pleiotropic effects in neoplastic behavior.
Cheng F, Hansson VC, Georgolopoulos G, Mani K. Cheng F, et al. Oncotarget. 2023 Mar 21;14:219-235. doi: 10.18632/oncotarget.28388. Oncotarget. 2023. PMID: 36944188 Free PMC article.
Focusing on GPC1, survival analyses of the clinical cancer patient data reveal statistically significant correlation between high expression of GPC1 and poor prognosis in 10 particular cancer types i.e., bladder urothelial carcinoma, brain lower grade glioma, …
Focusing on GPC1, survival analyses of the clinical cancer patient data reveal statistically significant correlation between high exp …
Glypican 1 promotes proliferation and migration in esophagogastric adenocarcinoma via activating AKT/GSK/β-catenin pathway.
Pratap A, Li A, Westbrook L, Gergen AK, Mitra S, Chauhan A, Cheng L, Weyant MJ, McCarter M, Wani S, Meguid RA, Mitchell JD, Cohen M, Fullerton D, Meng X. Pratap A, et al. J Gastrointest Oncol. 2022 Oct;13(5):2082-2104. doi: 10.21037/jgo-22-240. J Gastrointest Oncol. 2022. PMID: 36388647 Free PMC article.
BACKGROUND: Glypican 1 (GPC1) is a heparan sulphate proteoglycan cell membrane protein. It is implicated in driving cancers of the breast, brain, pancreas, and prostate; however, its role in esophagogastric cancer (EGAC) remains unexplored. The aim of the study was …
BACKGROUND: Glypican 1 (GPC1) is a heparan sulphate proteoglycan cell membrane protein. It is implicated in driving cancers of the br …
Identifying gene regulatory networks in schizophrenia.
Potkin SG, Macciardi F, Guffanti G, Fallon JH, Wang Q, Turner JA, Lakatos A, Miles MF, Lander A, Vawter MP, Xie X. Potkin SG, et al. Neuroimage. 2010 Nov 15;53(3):839-47. doi: 10.1016/j.neuroimage.2010.06.036. Epub 2010 Jun 22. Neuroimage. 2010. PMID: 20600988 Free PMC article. Review.
The imaging genetics approach to studying the genetic basis of disease leverages the individual strengths of both neuroimaging and genetic studies by visualizing and quantifying the brain activation patterns in the context of genetic background. Brain imaging as an …
The imaging genetics approach to studying the genetic basis of disease leverages the individual strengths of both neuroimaging and genetic s …
Glypican-1 stimulates Skp2 autoinduction loop and G1/S transition in endothelial cells.
Qiao D, Meyer K, Friedl A. Qiao D, et al. J Biol Chem. 2012 Feb 17;287(8):5898-909. doi: 10.1074/jbc.M111.325282. Epub 2011 Dec 27. J Biol Chem. 2012. PMID: 22203671 Free PMC article. Retracted.
We demonstrated previously that in brain EC, GPC1 regulates mitotic cyclins and securin as well as mitosis and that GPC1 is required for progression through the cell cycle. ...GPC1 may trigger the Skp2 autoinduction loop at least partially by suppressi …
We demonstrated previously that in brain EC, GPC1 regulates mitotic cyclins and securin as well as mitosis and that GPC1 …
Glypican-1-targeted antibody-drug conjugate inhibits the growth of glypican-1-positive glioblastoma.
Uchida S, Serada S, Suzuki Y, Funajima E, Kitakami K, Dobashi K, Tamatani S, Sato Y, Beppu T, Ogasawara K, Naka T. Uchida S, et al. Neoplasia. 2024 Apr;50:100982. doi: 10.1016/j.neo.2024.100982. Epub 2024 Feb 27. Neoplasia. 2024. PMID: 38417223 Free PMC article.
Immunohistochemical staining analysis of a glioblastoma tissue microarray revealed that GPC1 expression was elevated in more than half of the cases. GPC1-ADC, when bound to GPC1, was efficiently and rapidly internalized in glioblastoma cell lines. ...In concl …
Immunohistochemical staining analysis of a glioblastoma tissue microarray revealed that GPC1 expression was elevated in more than hal …
HSPGs glypican-1 and glypican-4 are human neuronal proteins characteristic of different neural phenotypes.
Oikari LE, Yu C, Okolicsanyi RK, Avgan N, Peall IW, Griffiths LR, Haupt LM. Oikari LE, et al. J Neurosci Res. 2020 Aug;98(8):1619-1645. doi: 10.1002/jnr.24666. Epub 2020 Jun 19. J Neurosci Res. 2020. PMID: 32562306
Here, we further examined phenotypical characteristics and GPC1 and GPC4 during neural differentiation of hNSCs in the presence of two neurogenic growth factors reported to bind to heparan sulfate: brain-derived neurotrophic factor (BDNF) and platelet-derived growth …
Here, we further examined phenotypical characteristics and GPC1 and GPC4 during neural differentiation of hNSCs in the presence of tw …
Overexpression of Annexin A2 promotes proliferation by forming a Glypican 1/c-Myc positive feedback loop: prognostic significance in human glioma.
Li X, Nie S, Lv Z, Ma L, Song Y, Hu Z, Hu X, Liu Z, Zhou G, Dai Z, Song T, Liu J, Wang S. Li X, et al. Cell Death Dis. 2021 Mar 12;12(3):261. doi: 10.1038/s41419-021-03547-5. Cell Death Dis. 2021. PMID: 33712571 Free PMC article.
In order to set up a reliable prediction system for the tumor grade and prognosis in glioma patients, we clarify the complicated crosstalk of Annexin A2 (ANXA2) with Glypican 1 (GPC1) and demonstrate whether combined indexes of ANXA2 and GPC1 could improve the progn …
In order to set up a reliable prediction system for the tumor grade and prognosis in glioma patients, we clarify the complicated crosstalk o …
Inactivation of BACE1 increases expression of endothelial nitric oxide synthase in cerebrovascular endothelium.
He T, d'Uscio LV, Sun R, Santhanam AVR, Katusic ZS. He T, et al. J Cereb Blood Flow Metab. 2022 Oct;42(10):1920-1932. doi: 10.1177/0271678X221105683. Epub 2022 Jun 8. J Cereb Blood Flow Metab. 2022. PMID: 35673977 Free PMC article.
Deletion of BACE1 caused upregulation of eNOS and glypican-1 (GPC1) in human BMECs treated with BACE1-siRNA, and cerebral microvessels of male BACE1(-/-) mice and male eBACE1(-/-) mice. ...In aggregate, our findings suggest that under physiological conditions, inactivation …
Deletion of BACE1 caused upregulation of eNOS and glypican-1 (GPC1) in human BMECs treated with BACE1-siRNA, and cerebral microvessel …
Extracellular Vesicular Analysis of Glypican 1 mRNA and Protein for Pancreatic Cancer Diagnosis and Prognosis.
Li H, Chiang CL, Kwak KJ, Wang X, Doddi S, Ramanathan LV, Cho SM, Hou YC, Cheng TS, Mo X, Chang YS, Chang HL, Cheng W, Tsai WN, Nguyen LTH, Pan J, Ma Y, Rima XY, Zhang J, Reategui E, Chu YS, Chang PM, Chang PH, Huang CF, Wang CH, Shan YS, Li CP, Fleisher M, Lee LJ. Li H, et al. Adv Sci (Weinh). 2024 Mar;11(11):e2306373. doi: 10.1002/advs.202306373. Epub 2024 Jan 10. Adv Sci (Weinh). 2024. PMID: 38204202 Free PMC article.
Utilizing an immune lipoplex nanoparticle (ILN) biochip assay, these findings demonstrate that glypican 1 (GPC1) mRNA expression in the exosomes-rich (Exo) EV subpopulation and GPC1 membrane protein (mProtein) expression in the microvesicles-rich (MV) EV subpopulati …
Utilizing an immune lipoplex nanoparticle (ILN) biochip assay, these findings demonstrate that glypican 1 (GPC1) mRNA expression in t …
Pharmacokinetics and Biodistribution of 89Zr-Miltuximab and Its Antibody Fragments as Glypican-1 Targeting Immuno-PET Agents in Glioblastoma.
Ghosh S, Fletcher NL, Huda P, Houston ZH, Howard CB, Lund ME, Lu Y, Campbell DH, Walsh BJ, Thurecht KJ. Ghosh S, et al. Mol Pharm. 2023 Mar 6;20(3):1549-1563. doi: 10.1021/acs.molpharmaceut.2c00760. Epub 2023 Jan 5. Mol Pharm. 2023. PMID: 36602058
Glioblastoma (GBM) is the most aggressive form of primary brain cancer, accounting for about 85% of all primary central nervous system (CNS) tumors. ...
Glioblastoma (GBM) is the most aggressive form of primary brain cancer, accounting for about 85% of all primary central nervous syste …
32 results